Glucose-regulated protein 78 (GRP78) binds directly to PIP3phosphatase SKIP and determines its localization
نویسندگان
چکیده
منابع مشابه
Glucose-Regulated Protein 78 (Grp78) Confers Chemoresistance to Tumor Endothelial Cells under Acidic Stress
OBJECTIVES This study was designed to investigate the activation of the unfolded protein response (UPR) in tumor associated endothelial cells (TECs) and its association with chemoresistance during acidic pH stress. MATERIALS AND METHODS Endothelial cells from human oral squamous cell carcinomas (OSCC) were excised by laser capture microdissection (LCM) followed by analysis of UPR markers (Grp...
متن کاملExpression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma
INTRODUCTION Multiple myeloma (MM) is a plasma cell neoplasm that is mostly incurable due to acquired resistance during the treatment course. Thus, we evaluated expression and release of glucose-regulated protein 78 kDa (GRP78/BiP), an endoplasmic reticulum (ER) based pro-survival chaperone involved in immunoglobulin folding and unfolded protein responses. RESULTS GRP78 protein expression in ...
متن کاملCharacterization and mechanism of stress-induced translocation of 78-kilodalton glucose-regulated protein (GRP78) to the cell surface.
Glucose-regulated protein (GRP78)/BiP, a major chaperone in the endoplasmic reticulum, is recently discovered to be preferably expressed on the surface of stressed cancer cells, where it regulates critical oncogenic signaling pathways and is emerging as a target for anti-cancer therapy while sparing normal organs. However, because GRP78 does not contain classical transmembrane domains, its mech...
متن کاملPRDM14 directly interacts with heat shock proteins HSP90α and glucose‐regulated protein 78
PRDM14 is overexpressed in various cancers and can regulate cancer phenotype under certain conditions. Inhibiting PRDM14 expression in breast and pancreatic cancers has been reported to reduce cancer stem-like phenotypes, which are associated with aggressive tumor properties. Therefore, PRDM14 is considered a promising target for cancer therapy. To develop a pharmaceutical treatment, the mechan...
متن کاملtherapeutic potential of glucose regulated protein 78 in cancer
endoplasmic reticulum has a critical role in the synthesis and folding of secretory and membrane proteins. high accumulation of proteins in er activates the unfolded protein response and glucose regulated protein 78 or gpr78 plays an essential role in this pathway. unfolded protein response is activated in cancerous cells due to their adverse condition to survive and it has been shown that grp...
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ژورنال
عنوان ژورنال: Genes to Cells
سال: 2016
ISSN: 1356-9597
DOI: 10.1111/gtc.12353